• SHBG is a protein made by your liver. It binds tightly to 3 sex hormones found in both males and females. These hormones are estrogen, dihydrotestosterone (DHT), and testosterone. SHBG carries these 3 hormones throughout your blood.

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  • Although SHBG binds 3 hormones, the hormone that's critical in this test is testosterone. SHBG controls the amount of testosterone that your body tissues can use. Too little testosterone in males and too much testosterone in females can cause problems. The level of SHBG in your blood changes because of factors such as sex and age. It can also change because of obesity, liver disease, and hyperthyroidism.